Case : The 1752, Joshua and Naomi Collins, together with their son Barnabas, they decide to move, from Liverpool, England, in America. Even an ocean, Nevertheless, he is not enough, to escape the curse that haunts their family. Two decades later, Barnabas (Johnny Depp) he has the world at his feet…or at least the city of Collinsport, in Maine. Lord of the manor of Collingwood, Barnabas is rich, powerful and an irresistible playboy... until he makes the big mistake of breaking Angelique Bouchard's heart (Eva Green). Witch, in every sense of the word, Angelique condemns him to a fate worse than death: turns him into a vampire and then buries him alive. Two centuries later, Barnabas is accidentally freed from his grave, and goes out to 1972, a world very different from his own. He returns to the Collingwood Mansion, only to discover that his property is destroyed. The dysfunctional remnants of Collins, they don't have much better luck, as they each have their own dark secrets. Collins' matriarchal figure, Elizabeth Collins Stoddard (Michelle Pfeiffer) she has called the psychiatrist, Dr. Julia Hoffman (Elena Boman Carter), to help with her family's problems. They live in the mansion, also, Elizabeth's brother, Roger Collins (Johnny Lee Miller), her religious teenage daughter, Carolyn Stoddard (Chloe Moretz) and his ten-year-old son Roger, David Collins (Gulliver McGrath).